ATP5F1E and myocardial ischemia: Remarkably, quercetin has been shown to act as an inhibitor of the ATP hydrolytic activity but not of the ATP synthesis activity of the mitochondrial F1,F0-ATPase, and it has been proposed that preventing the destruction of ATP by the mitochondrial F1,F0-ATPase affords cardioprotective benefit during cardiac ischemia [216].