Autophagy is strictly regulated by upstream modulators, namely, the PI3K/AKT/mTOR signaling pathway; natural bioactive substances stimulate autophagy via this mechanism in cancer cells; in fact, it was observed that blocking EFGR and the PI3K/AKT/mTOR signaling cascade may help cancer cells engage in autophagy: there is evidence of a significant reduction of the levels of EFGR, PI3K, phosphorylated PI3K, and AKT protein expression after F3 incubation [119] (Table 1 and Figure 1). The gene discussed is MTOR; the disease is cancer.