Therefore, using these kinases and the genes they regulate, the targeting effect of G. lucidum on MAPK pathways in leukemia cells has been studied [120]: ERK/MAPK signaling transduction is a traditional pathway that is also involved in the pathogenesis of leukemia, and a constitutive activation was found in some acute leukemic cells; this statement is supported by previous studies finding that untreated HL-60 cells both in vitro and in vivo had overexpression of p-ERK1/2. This evidence concerns the gene MAPK3 and leukemia.