apheresis, based on clinical (degree of vascular lesions at baseline) and laboratory (hypercholesterolemia, high levels of CRP and fibrinogen) findings; furthermore, a specific protocol for the maintenance phase should be set up, with the goal of keeping under control the key players in atherosclerotic progression (fibrinogen, inflammatory and endothelial markers, ROS) and reducing the risk of long-term complications. The gene discussed is CRP; the disease is familial hypercholesterolemia.