TP53 and acute myeloid leukemia: Xpo7, a putative nuclear/cytoplasmic transporter, was recently identified as a factor necessary for the survival of Trp53-knockout (KO) AML cells with the performance of genome-wide CRISPR-Cas9 screens using Trp53-KO and WT mouse AML cells, indicating a synthetic lethal relationship between TP53 and XPO7 [110].