It has also been demonstrated that TIM-3 is overexpressed in LCs and that TIM-3+ AML leukemic stem cells (LSCs) secrete galectin-9 in an autocrine loop that regulates self-renewal of these cells via enhanced NF-κB and β-catenin signaling [80,81]. The gene discussed is HAVCR2; the disease is acute myeloid leukemia.