MDM2 and acute myeloid leukemia: A phase 1/1b study has evaluated the use of idasanutlin (IDASA), an oral MDM2 inhibitor (MDM2i), either alone or in combination with AraC, in unfit for IC patients with R/R or ND AML and has demonstrated a coCR rate of 18.9% and 35.6% in patients receiving monotherapy or combination treatment, respectively [102].