CRTAP and osteogenesis imperfecta: Crtap−/− mice models for recessive OI were treated with 25 mg/kg Scl-Ab twice a week for 6 weeks in the young adult model (6 weeks old) and for 7 weeks in the pediatric ones. The improvement in bone mass, bone formation, parameters of strength, and trabecular microarchitecture were reported, and there was a decrease in the number of osteoclasts without complications.