In order to achieve excellent classification criteria for new-onset SLE, the EULAR/ACR proposed the use of positive ANA titers as a statutory entry criterion, with subsequent additive weighted criteria divided into seven clinical (constitutional, renal hematological, neuropsychiatric, serosal, musculoskeletal, and mucocutaneous) and three immunological (complement proteins, anti-phospholipid antibodies, and SLE-specific antibodies) components [66]. This evidence concerns the gene VTN and systemic lupus erythematosus.