Thus, molecular diagnosis with the following genes has been incorporated: IL1RN, MEFV, MVK, TNFRSF1A, NLRP12, NLRP3, NOD2, LPIN2, PSMB8, PSTPIP1, which provides a rapid and effective genetic screening for early treatment as the delayed treatment can cause major complications such as severe osteomyelitis. This evidence concerns the gene IL1RN and osteomyelitis.