LPL and Hypercholesterolemia: Steroids are associated with hypercholesterolemia as they stimulate fatty acid synthesis, induce insulin resistance, increase the synthesis of very low-density lipoprotein (VLDL), reduce the activity of lipoprotein lipase (LPL), and enhance the activity of hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase [36,37].