An interesting finding is that although PLAUR’s expression level was positively associated with the “M2 macrophage” component, we also observed that the PLAUR protein and the canonical M2 marker (CD163 and CD206) were adjacent or colocalized in the frozen sections of glioma tissue, but a higher M1 macrophage fraction was also detected (Figure 5, Figure S3). The gene discussed is CD163; the disease is central nervous system cancer.