Pyroptosis induced by Prostaglandin E2 (PGE2) has been shown to influence the progression of endometriosis by modifying the migration of pyroptotic cells and increasing the expression of High Mobility Group 1 Protein (HMGB1), the adhesion protein E-cadherin, and the cytoskeletal intermediate filament vimentin. This evidence concerns the gene HMGB1 and endometriosis.