To understand the reason underlying this discrepancy, we analyzed RNA sequencing data of the corresponding untreated GBM sphere lines (Figure 5C) and found that 006 cells expressed the highest level of CLK4 (a preferred target of 2; Table 1) and the lowest level of DYRK2 (a preferred target of 1; Table 1). The gene discussed is DYRK2; the disease is glioblastoma.