RB1 and pachyonychia congenita: In experimental models of PC, while knockout of either RB1 or TP53 failed to give rise to invasive carcinomas [58,59,60,61], simultaneous inactivation of both molecules resulted in poorly differentiated PCs with co-expression of luminal and NE markers, de novo ADT resistance, and visceral metastatic spread [61,62], features reminiscent of AVPC.