CDH1 and cancer: Although autophagic degradation of E-cadherin may enhance the activation of the EMT program, other studies have shown the role of autophagy in regulating the degradation of EMT inducers, such as mediators of EMT-related signaling pathways, ECM, and cytoskeleton-related proteins, as well as EMT-TFs, which may limit the metastatic potential of cancer cells.