It has been documented that obesity in BC is directly linked with CRF, and this association is probably attributed to the high levels of circulating inflammatory cytokines, i.e., tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), as well as blood fatty acid imbalance [41]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.