Firstly, we should exclude hepatic virus infection such as HAV, HBV, HCV, HEV CMV, EBV, and HSV using the related bioumoral tests (anti-HAV IgM, HBsAg, anti-HBc IgG, anti-HBc IgM, HBV DNA, anti-HCV, HCV RNA, anti-HEV IgG, anti-HEV IgM, HEV RNA, anti-CMV IgM, CMV DNA, anti-EBV IgM, EBV DNA, anti-HSV IgM, and HSV DNA). The gene discussed is CD40LG; the disease is viral infectious disease.