In one study, Ino et al. compared the level of tumor-infiltrating lymphocytes in PDAC resections to simulated FNA “biopsies” taken from the resection specimen, finding that the level of CD8+ T cells was only moderately correlated (r = 0.46) [100]; the group estimated that averaging measurements from five biopsies would be required to achieve a near-perfect correlation. Here, CD8A is linked to neoplasm.