Genetic deletion of Sonic Hedgehog Signaling Molecule (Shh) or pharmacologic inhibition of SHH in various PDAC mouse models abrogated the desmoplastic stroma and reduced the numbers of ɑSMA+ myofibroblasts and myeloid cells in the TME, but those treatments concurrently led to an increase in tumor vascularity and actually accelerated tumor growth [191,199]. The gene discussed is SHH; the disease is neoplasm.