Cancer patients suffering from renal cell carcinoma (RCC) and non-small-cell lung cancer (NSCLC) treated with antiprogrammed cell death ligand-1 (PD-L1) or PD-L1 plus CTLA-4 mAb monotherapy who were also undergoing treatment with antibiotics (β-lactam or quinolones for pneumonia or urinary tract infections) in the beginning were examined for thirty days for gut microbiota diversity and composition leading to dysbiosis. Here, CD274 is linked to hereditary clear cell renal cell carcinoma.