RHO and neoplasm: It has been shown that RACK1 is closely related to tumor progression [19,21,22,23,24,25] due to its modulation of multiple signaling pathways including PKC, receptor tyrosine kinase/PI3K/AKT, ERK/MAPK, STAT3, Src/FAK, NF-κB, Wnt/β-catenin, and RhoA/Rho pathway [26,34,35,36,37].