Adenovirus-mediated gene delivery of miR-223 in two inflammatory-associated models of HCC hindered tumor development and progression by inhibiting angiogenesis and hypoxia-mediated PD1/PD-L1 activation in T cells and macrophages, proving the therapeutic potential of miR-223 in blocking the immunosuppressive tumor microenvironment in HCC [109]. This evidence concerns the gene PDCD1 and neoplasm.