HSPB1 and hepatocellular carcinoma: An elegant study by Sun et al. described the engineering of EVs with miR-654-5p by in vitro electroporation (m654-sEV) and reported their effectiveness in sorafenib sensitization in preclinical models derived from SR-resistant HCC cells through the direct targeting of the ferroptosis inhibitor HSPB1 (heat shock factor-binding protein 1) [72].