CTLA4 and neoplasm: With regard to ICIs, the modulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed death cell protein 1 (PD-1)/programmed death ligand 1 (PD-L1), LAG3, B7-H3, and B7-H4 on CD8+ tumor-infiltrating lymphocytes (TILs) are the primary targets [5].