Outlook: The identification of UTX (KDM6A) as putative therapeutic target and/or potential prognostic biomarker for HNSCC patients undergoing radiotherapy draws our attention to the currently upcoming discussion about the importance of X- and Y-linked tumor suppressor genes and/or oncogenes influencing sex-specific cancer incidence and prognosis [44]. Here, KDM6A is linked to head and neck squamous cell carcinoma.