METTL3 and glioma: Individual m6A RNA methylation regulators, including METTL3, ALKBH5, YTHDF2, and IGF2BP3, have been assessed in patient datasets to examine their expression levels across normal tissues, lower-grade gliomas, and glioblastomas, as well as their prognostic significance [19,20,21,22,23,24,25,26].