Given the numerous pathways activated by IL11 signalling (the ligand of IL11RA), including JAK-STAT, Ras-MAPK, PI3K-AKT, and NF-κB [87,88], the complexity of signalling and interaction could mean tissue- and pathway-specificity for the effect of IL11RA upregulation on neuroblastoma. The gene discussed is AKT1; the disease is neuroblastoma.