Next, we focused on the top 15 genes in the TCA genes from the TCGA TARGET GTEx dataset (Figure 1B) and found that the expression of succinate coenzyme A ligase (SUCLG2), succinate dehydrogenase B (SDHB) and fumarate hydratase (FH) significantly improved the prognosis of colon adenocarcinoma (COAD) in the TCGA cohort (Figure 1C). This evidence concerns the gene SDHB and colon adenocarcinoma.