We previously identified the level of a cleaved peptide of Filamin A (FLNA) in serum, when combined with prostate volume and age among men who all had elevated PSA levels between 4 and 10 ng/mL, that provided superior predictive performance compared to PSA in distinguishing between men with BPH and men with PCa [4]. The gene discussed is FLNA; the disease is posterior cortical atrophy.