CXCL13 and neoplasm: However, we found a greater density of CXCL13+ cells in TLSs compared to the tumor (CXCL13_TLS/CXCL13_T ratio, p = 0.031 (Figure 2E)) in responders vs. non-responders, which is believed to be influenced by interaction between CXCL13+ and CD20+ cells within the TLS compartment [9,22].