Previous studies did not assess the potential predictive role of CXCL13+ cells in IM, but Bindea et al. revealed that the absence of CXCL13 in individuals with colorectal tumors led to a decrease in the concentration of B cells in the invasive border of the tumors, resulting in a substantial increase in the likelihood of disease recurrence [40]. Here, CXCL13 is linked to colorectal neoplasm.