This study was designed to evaluate the influence of BZA on ERα and BRCA1 in T-47D and MCF-7 breast cancer cell lines, utilizing Western blot analyses, cellular viability assessments, apoptosis assays, and Reverse-Transcription Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) studies. The gene discussed is ESR1; the disease is breast carcinoma.