Liu et al. showed that B16 melanoma mouse cells presenting stiffness <0.3 KPa, considered as “soft” cells, represent a subpopulation of melanoma cells that is able to survive to cytotoxic CD8+ T lymphocytes by using a mechanism preventing perforin from drilling a pore, which in turn leads to T cell killing evasion [60]. The gene discussed is CD8A; the disease is melanoma.