Thus, myofibroblasts and macrophages, both important stroma cell populations in pancreatic tumors and metastases [87,88], were already shown to induce L1CAM expression in PDAC cells [89,90,91] Altogether, these data indicate a robust phenotype stability of Holo- and Paraclones of either PDAC cell line under constant environmental conditions. The gene discussed is L1CAM; the disease is pancreatic neoplasm.