PIEZO1 and cancer: PIEZO1 expression has also been demonstrated to contribute to various physiological processes within the hallmarks of cancer, including epithelial–mesenchymal transition (EMT) [14,15], angiogenesis [15,16,17], hypoxia [15,16,18], metabolic alteration [19], inflammation [18], and the functional gain or loss of various signaling pathways [14,16,20,21,22].