Remarkably, as astrocytic genes were among the most upregulated genes in SCZ and bipolar disorder, and the expression of TGFB2 in induced pluripotent stem cells (iPSC)-derived astrocytes was three-fold higher than in neurons [40], the expression of over 75% of dysregulated genes in the disease state (in particular astrocytic genes) exhibited a direct correlation with TGFB2 expression. This evidence concerns the gene TGFB2 and bipolar disorder.