SQSTM1 and Alzheimer disease: For example, the protective effects of p62 (SQSTM1)-engineered LAB in AD are linked to their increasing abundance in the family of Ruminococcacea (a major producer of butyrate), reducing neuronal oxidative stress and inflammation, regulating the ubiquitin–proteasome system and autophagy, and attenuating amyloid peptide levels [137].