On the other hand, obesity is common among patients with binge eating disorder (BED) [18], leading to a considerable medical burden due to the metabolic complications and the decrease in quality of life [19]; novel research is trying to disentangle the genetic contribution of the NUCB2/nesfatin-1 gene and the co-occurrent BED [20]. Here, NUCB2 is linked to obesity due to melanocortin 4 receptor deficiency.