As noted, dysregulated eating behaviors are a primary factor that contributes to the increased rate of obesity worldwide [14] and genetic studies are growing to elucidate the possible link between the NUCB2/nesfatin-1 gene and the role of single nucleotide polymorphisms in the development of obesity (OBE) [15]. The gene discussed is NUCB2; the disease is obesity due to melanocortin 4 receptor deficiency.