Several recent studies have highlighted the potential prognostic markers of outcome in severe sepsis, including the central venous minus arterial carbon dioxide pressure to arterial minus central venous oxygen content ratio (Pcv-aCO2/Ca-cvO2 [141,142], the CRP/albumin ratio [86,143], and lactate clearance [65,113,116,144]. The gene discussed is CRP; the disease is Sepsis.