SNRPN and Angelman syndrome: The SNRPN gene (OMIM 182279) is a bicistronic imprinted gene located within an imprinted gene cluster on chromosome 15, associated with Prader–Willi syndrome (PWS) and Angelman syndrome (AS), two clinically different neurogenetic disorders caused by the lack of the maternal or paternal 15q11–q13 allele, respectively.