When PE overlaps with chronic arterial hypertension, the International Society for the Study of Hypertension in Pregnancy (ISSHP) 2021 [2] recommendations consider angiogenic imbalance, as demonstrated by an increase in the maternal sFlt-1/PlGF ratio and a reduction in maternal PlGF levels, to be a diagnostic criterion for de novo PE. The gene discussed is PGF; the disease is hypertensive disorder.