IL-1β (β = 0.400) compared to IL-6 (β = 0.201) and clinical manifestations (β = 0.137) had the highest standardized coefficient values, so it can be considered that this cytokine is the best predictor of a lower health-related quality of life in a model controlled for clinical manifestations in adolescents with allergic rhinitis. The gene discussed is IL6; the disease is allergic rhinitis.