HLA-DRB1 and type 1 diabetes mellitus: Researchers found that in the Nenets population, there was a lower frequency of occurrence of two risk haplotypes, such as DRB1*17(03)-DQA1*0501-DQB1*0202 and DRB1*01-DQA1*0101-DQB1*0501, as well as higher frequency of two protective haplotypes DRB1*11-DQA1*0501-DQB1*0301 and DRB1*13-DQA1*0102-DQB1*0602/8/DRB1*13-DQA1*0103-DQB1*0602/8 compared with two groups of Russian populations; that probably contributes to low susceptibility to T1DM in Nenets [24].