In spite of some authors considering RPL30 as a classical reference gene for cancer research due to its stable expression [46], our results showed that the overexpression of RPL30 is a hallmark of the dead group in PaCa, being the highest overexpressed gene in this GDC cohort (26.06-fold on average). Here, RPL30 is linked to permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.