HIF1A and pancreatic neoplasm: In particular, the HIF1A protein induces metabolic reprogramming in the hypoxic condition of a pancreatic tumor and up-regulates multiple genes as cyclin D1, Met protooncogene, receptor Tyrosine kinase (MET, formerly HGFR), vascular endothelial growth factor A (VEGFA), carbonic anhydrase IX (CAIX), fibronectin, and glucose transporter 1 (GLUT1) [6].