For example, whether SRPK1 has interacting partner molecules that jointly guide the occurrence and development of gliomas, whether knocking out SRPK1 will induce cell autophagy and ferroptosis, and whether these forms of cell death are related to the Wnt/β-catenin and JAK-2/STAT-3 signaling pathways, are all worth further investigation. This evidence concerns the gene STAT3 and glioma.