HB-EGF (p = 0.0371), delta miR-195 (p < 0.0001), PT (p = 0.0088), fibrinogen (p = 0.0094), D-Dimers (p = 0.0242), creatinine (p = 0.0269) were all significantly increased in the COVID-19 severe group. This evidence concerns the gene F2 and COVID-19.