We may speculate that the endothelial dysfunction observed in psoriasis, together with episodes of local sterile meningeal inflammation, local hypersensitivity of pain pathways, and the release of the proinflammatory cytokines, involved in the pathogenesis of pso-riasis, may promote migraine, by sensitization of meningeal nociceptors and peripheral nerve endings, via the activation of mitogen-activated p38 protein kinases and increased dural mechano-sensitivity [9,10,11,12]. Here, MAPK14 is linked to psoriasis.