TNF and neoplasm: This exploration begins by scrutinizing the Cellular Components of the TME, where a consortium of cytokines, including Interleukin-10 (IL-10), IL-6, IL-4, IL-1β, IL-17, and Tumor Necrosis Factor-Alpha (TNF-α), orchestrates a multifaceted environment that collectively impacts immune cells, stromal elements, and tumor cells.