Furthermore, array-based gene expression profiling in renal tissue of adult HAN:SPRD (Cy/+) rats revealed altered aqp3/aqp4 transcriptional regulation, indicating that impaired ANKS6–ANKS3 binding interferes with vasopressin-mediated pathways, which are either directly or indirectly associated with polycystic kidney disease. This evidence concerns the gene ANKS6 and polycystic kidney disease.