LEP and Infertility: Together, they are responsible for regulating the enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2), which promotes H3K27me3 and CBP/p300, which in turn promotes H3K27ac, causing the Cartpt promoter to increase its sensitivity to leptin and predisposing female offspring from diabetic pregnancies to an increased risk of infertility during adulthood (Figure 2) [82].