LEP and gestational diabetes: In addition, an elevated risk of infertility in adulthood has been reported in mice exposed to GDM due to a decrease in 5-methylcytosine (5 mC) and an increase in 5-hydroxymethylcytosine (5 hmC) levels in the cocaine- and amphetamine-regulated transcript Cart prepropeptide (Cartpt) promoter, which together cause leptin sensitivity to increase in the abovementioned promoter and an increased risk of ovarian dysfunction by affecting folliculogenesis [82].