One study analyzed the offspring of rats under these conditions, and interestingly, differences in acetylation were found in histones H3K9 and H3K14, as well as the trimethylation of histones H3K4 and H3K27 in offspring exposed to diabetes during pregnancy and in the offspring of mothers fed an HFD in the gene heat shock protein 1A (Hspa1a) (Figure 2) [101], which indicated that the maternal condition is capable of producing epigenetic marks in histones related to susceptibility to cardiac pathologies. This evidence concerns the gene HSPA1A and diabetes mellitus.