Of all the genes affected by the maternal diet, about 25–33% had DMRs, supporting the conclusion that an HFD in the gestational stage can cause variation in DNA methylation, reduced insulin sensitivity, and altered expression in more than 3900 liver genes [81], as well as an increased risk of conditions such as diabetes and obesity as a consequence. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.