INS and Insulin resistance: By collecting placenta tissue from the fetal side, the association between maternal insulin resistance and epigenetic changes in the genome was addressed; based on its role in transferring nutrients to the fetus, an increase in the histone modifications in the Encyclopedia of DNA Elements histone modifications database, predominantly caused by H3K27me3, suggests that the epigenetic changes (including DNA and histone modifications) are related to maternal insulin sensitivity in the prenatal stage (Figure 3) [105].