A study revealed elevated methylation in the ArfGAP with GTPase domain, ankyrin repeat, and PH domain 2 (Agap2) gene, which was found to be upregulated, suggesting a connection between these changes and an increased risk of T2DM and obesity in the adulthood of the exposed offspring caused by the induction of hyperinsulinemia during the fetal stage [79]. This evidence concerns the gene AGAP2 and hyperinsulinism.