Of the 19 proteins with genetic instruments in both the CSF and brain, three were associated with at least one outcome in one tissue only (brain-derived PPAC with sleep duration, brain-derived C4b with fluid intelligence score and schizophrenia liability, and CSF-derived CNTN2 with schizophrenia liability), four (MSP, ILT-2, GSTP1, and ApoE2) had associations consistent in the brain and CSF (Table 1), and 12 did not associate with any outcome in either tissue. This evidence concerns the gene MST1 and schizophrenia.