CXCL8 and acute coronary syndrome: In patients with acute coronary syndrome, IL-8 plasma levels correlated with the IL-8 251 A>T polymorphism; the highest IL-8 plasma concentrations were found in carriers of the IL-8 −251 AA genotype, intermediate levels among carriers of the −251 AT genotype, and the lowest levels in individuals carrying the −251 TT genotype [38].