Furthermore, indirect confirmation of our theory is supported by the fact that in Group II, the number of CD20- and CD138-positive cells remains lower than in Group I. In acute appendicitis, one of the leading factors in inflammation development is the bacterial intestinal microflora, which is activated in response to the blockage of the appendix lumen by enlarged lymphoid tissue, triggering a cellular immune response. The gene discussed is SDC1; the disease is appendicitis.