Yao et al. discovered that the inhibition of CDK9 leads to the suppression of the SIRT1-FOXO3-BNIP3 axis, resulting in the inhibition of PINK1-PRKN-mediated mitophagy, which helped overcome drug resistance in hepatocellular carcinoma [44]. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.