Statistical analyses determined anxiety as a bruxism risk factor (OR = 2.54; 95% CI: 1.20–5.38; p-value = 0.015), and GWAS highlighted three novel genes potentially associated with bruxism: NLGN1 (topSNP = rs2046718; p-value = 2.63 × 10−7), RIMBP2 (topSNP = rs571497947; p-value = 4.68 × 10−7), and LHFP (topSNP = rs2324342; p-value = 7.47 × 10−6). The gene discussed is NLGN1; the disease is Anxiety.