SLC2A8 is expressed by the human placental trophoblast during pregnancy [48] and has previously been related to reduced fetal growth [49]; SLC2A8 was hypomethylated in the peripheral blood of small-for-gestational-age (SGA) infants aged 12 months and negatively associated with obesity measures (BMI z-scores and fat mass) at 12 and 24 months [50]. This evidence concerns the gene SLC2A8 and obesity due to melanocortin 4 receptor deficiency.