HADHA and metabolic disease: The key findings from our study include (1) an in silico approach, showing that those differentially methylated CpGs/genes were likely involved in several metabolic pathways related to cell proliferation and development, with potential effects on metabolic diseases; and (2) the identification of HADHA and SLC2A8 genes, which were differentially methylated in both placenta and umbilical cord tissue and related to several metabolic parameters in the offspring at 6 years.